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    Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically to ketamine. Tiletamine hydrochloride exists as odorless white crystals. It is used in veterinary medicine in the combination product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as polar bears and wood bison. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries. Recreational use of telazol has been documented. Animal studies have also shown that tiletamine produces rewarding and reinforcing effects. Tiletamine products are classified as Schedule III controlled substances in the United States
  2. If you don't mind we might use that chart and add 2fdck dck to it and have it on site may be usefull!
  3. Depression researchers at Black Dog Institute and University of NSW had to abort a "promising" pilot trial into the efficacy of ketamine nasal sprays after patients experienced psychotic-like effects and temporary loss of fine motor skills. The researchers were hopeful the trial would work as an earlier study in the US had shown ketamine - an anaesthetic drug shown to have rapid antidepressant effects - could be safely delivered using a nasal spray. https://www.google.com/amp/s/amp.smh.com.au/healthcare/depression-researchers-stop-ketamine-nasal-spray-trial-because-of-psychotic-like-effects-20180315-p4z4hm.html
  4. The gallery is now open! Registered Users will now be able to view gallery and comment on images as well as rate them. Members will be able to create there own albums and upload images!
  5. Welcome to keta.info we hope you are enjoying it here! So you are looking to become a member? Well its not hard and its not easy.... All you have to do is be active! 😛 have input and be around the community. Below are the requirements: Content Count more than 20 (Posting is content) Reputation more than 5 (People liking what you posted / commented)
  6. What is MXE: Methoxetamine, abbreviated as MXE, is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed for grey market distribution. MXE is an arylcyclohexylamine.[ It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP. What are the effects: MXE is reported to have a similar effect to ketamine. It was often believed to possess opioid properties due to its structural similarity to 3-HO-PCP, but this assumption is not supported by data, which shows insignificant affinity for the µ-opioid receptor by the compound. Recreational use of MXE has been associated with hospitalizations from high and/or combined consumption in the US and UK. Acute reversible cerebellar toxicity has been documented in three cases of hospital admission due to MXE overdose, lasting for between one and four days after exposure. MXE was designed in part in an attempt to avoid the urotoxicity associated with ketamine abuse; it was thought the compound's increased potency and reduced dose would limit the accumulation of urotoxic metabolites in the bladder. Like ketamine, MXE has been found to produce bladder inflammation and fibrosis after high dose, chronic administration in mice (although the dosages used were quite large). Reports of urotoxicity in humans have yet to appear in the medical literature.
  7. I believe some of the site should be member only and i would like to have input from you guys (The Community) to decide what is and what isnt. Thanks Please post below you views on this.
  8. The chemical was spotted by drug-testing organisation The Loop in a club in Durham – which found ‘multiple samples’. The drug is a ‘new psychoactive substance’ (NPS), a chemical derivative similar to those sold as legal highs – and often made abroad in illicit labs and bought online by dealers. Such substances can be much stronger, and more dangerous, than the drugs they are based on, experts warn. The Loop said that it found ‘2-FDCK (2-fluorodeschloroketamine) sold as ketamine. The new chemical is much stronger than ketamine (Getty) The organisation said, ‘Tested by The Loop in Durham, UK. ‘About 1.5x more potent than ketamine with 2-3x longer duration.’
  9. 2-FDCK 2-Fl-2'-Oxo-PCM (also known as 2-Fluorodeschloroketamine, 2-FDCK, and inaccurately as 2-Fluroketamine, Fluoroketamine, and 2-FK) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like ketamine and deschloroketamine and is reported to produce similar effects. Like other dissociative substances, it is primarily sought by recreational users for its ability to induce a hallucinogenic "out of body" state referred to as "dissociative anesthesia" (although the extent to which this occurs is highly dose-dependent). It has recently become available through online research chemical vendors where it is being sold as a designer drug replacement for ketamine. There is very little information on the pharmacology, metabolism or toxicity of 2-fluorodeschloroketamine. It has an extremely brief history of human use. It is strongly advised to use harm reduction practices if using this substance. Pharmacology Further information: NMDA receptor antagonist Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as DCK and ketamine. With this in mind, 2-Fluorodeschloroketamine is thought to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “K-hole.”
  10. DCK Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is a dissociative anesthetic that has been sold online as a designer drug. It has also been proposed for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation at doses of 2 mg per day. Deschloroketamine research chemical in the arylcyclohexylamine class. It’s very close to ketamine with its structure and it’s closer to ketamine and MXE than to PCP-like dissociatives with its effects. It might have some antimicrobial properties, but those have only been minimally investigated. If those properties are real, they may provide another reason to limit your frequency of exposure. The drug is more potent than ketamine and lasts longer. Deschloroketamine = AC1L935Y; DCK; 2′-Oxo-PCM; O-PCM; 2-Phenyl-2-(methylamino)cyclohexanone PubChem: 437168 Molecular formula: C13H17NO Molecular weight: 203.285 g/mol IUPAC: 2-(methylamino)-2-phenylcyclohexan-1-one This Information will be updated when more information arises.
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